Nature Metabolism<\/a>.<\/p>\n‘Biological systems are analog, programmed by genetics, updated slowly by evolution and controlled by ions flowing through insulated membranes,’ the scientists explained.\u00a0<\/p>\n
‘Electronic systems,’ they wrote, in contrast, ‘are digital, programmed by readily updatable software and controlled by electrons flowing through insulated wires.’\u00a0<\/p>\n
Working out of\u00a0ETH Z\u00fcrich, a public research university in Switzerland, the researchers developed an intentionally simple system that uses\u00a0World Health Organization (WHO)-approved and US Food and Drug Administration (FDA)-licensed acupuncture needle electrodes to deliver modest life-saving jolts.<\/p>\n
Their DART system, according to the study, only has to deliver 10 seconds of DC current at 4.5 volts once per day to stimulate enough insulin production to regulate blood-sugar levels for diabetics.<\/p>\n
The battery-powered DART\u00a0interface essentially splits tiny amounts of water inside human cells into highly electrically charged ions, or ‘reactive oxygen species’ using the oxygen in ordinary H2O.\u00a0<\/span><\/p>\nThe team, led by molecular biologist Jinbo Huang at ETH Z\u00fcrich, was able to fine-tune sub-cellular elements via gene-therapy injections \u2014 including the ‘Kelch-like ECH-associated protein 1’ \u2014 into helping them produce insulin in response to these charged oxygen molecules.\u00a0<\/span><\/p>\nSpecifically, they created synthetic ‘antioxidant-response elements’ (AREs) which would activate specially made, insulin-producing theraputic transgenes.\u00a0<\/span><\/p>\nThe AREs would thus help make insulin in the course of doing their normal duties, attempting to tamp down those highly charged oxygen ions, as created by the acupuncture electrodes.<\/span><\/p>\nHuang and his team were able to show that the DART system could activate insulin-producing gene-based therapies that had been injected into human embryonic kidney cells, human stem cells, and various lab rodent models.\u00a0<\/p>\n
This\u00a0ETH Z\u00fcrich group<\/span>\u00a0hopes that their DART system will ‘set the stage for wearable-based electro-controlled gene expression.’\u00a0<\/p>\nDART, they wrote, has ‘the potential to connect medical interventions to an internet of the body or the internet of things.’<\/p>\n<\/div>\n
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